A faster, cleaner and greener way to synthesize N-heterocycles…….

As for as my knowledge goes many of the drugs ( more than 200 brand-name drugs) are nitrogen-containing ring-shaped structure (N-heterocycle). Manufacturing these drugs depends on the ability to synthesize N-heterocycles, but most synthetic reactions take a long time (multiple steps) and produce toxic waste byproducts along with use of hazardous chemicals such as hydrazine hydrate or acid hydrazides etc. Driver and his coworkers have devised a chemical reaction that creates a carbon-nitrogen bond, such as in the N-heterocycle, using an azide. Driver's reaction reduces the number of steps needed to synthesize the N-heterocycle molecules along with this, the more advantage of this reaction is 'nitrogen gas' as the only by product. Its really interesting indoles, pyrroles, carbazoles and benzimidazoles have been synthesized in very good yields. Congrats Dr. Driver and I hope this group,will come with more N-Heterocycles via this azide route.…..