Breaking carbon-hydrogen bonds: Cheap, easy 'kitchen chemistry' developed to perform formerly complex synthesis

Breaking carbon-hydrogen bonds: Cheap, easy 'kitchen chemistry' developed to perform formerly complex synthesis

Researchers synthesize wound-healing peptides

Researchers synthesize wound-healing peptides

Erythromycin A produced in E. coli for first time: Biosynthetic breakthrough paves way for other pharmaceuticals

Erythromycin A produced in E. coli for first time: Biosynthetic breakthrough paves way for other pharmaceuticals

MIT develops safer, simpler way to attach phosphorus to organic compounds

MIT develops safer, simpler way to attach phosphorus to organic compounds

Chemists grow crystals with a twist -- and untwist

Chemists grow crystals with a twist -- and untwist

Palau'amine synthesis achieved....

Compound, called Palau'amine,  a compound found in sponge off Palau, an island nation in the Pacific Ocean, that has shown anticancer, antibacterial, and antifungal activities. Many synthetic researchers were trying this challenge, but it is a team of scientists lead by Prof. Phil S. Baran from The Scripps Research Institute,  that has finally completed the quest.....

 

 

 

Ref : http://www3.interscience.wiley.com/journal/123227557/abstract?CRETRY=1&SRETRY=0

New method for producing 'libraries' of important carbohydrate molecules

New method for producing 'libraries' of important carbohydrate molecules

Complex organic molecules speed development of new drugs

Complex organic molecules speed development of new drugs

Scripps Research Team Wins Global Race To Achieve Landmark Synthesis Of Perplexing Natural Product

Scripps Research Team Wins Global Race To Achieve Landmark Synthesis Of Perplexing Natural Product

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Tamiflu starting from D-ribose an efficient inexpensive method....

We know the recent hue and cry about the stock piling of Tamiflu (Oseltamivir) and there by the deficiency of the drug. The commercially (see the below scheme; source : wikipedia) used method i.e., Karpf / Trussardi synthesis make use of  Shikimic acid. Many researchers have tried alternative raw materials for the synthesis of the drug and are successful also (see other schemes).

Now Anqi Chen and Christina  Chai of Shionogi & Co., Ltd have come up with a new process for making the drug that does not use shikimic acid. They found that D-ribose, a naturally-occurring sugar produced by fermentation in large scales, potentially provides an inexpensive and abundant source of starting material for making the drug. D-ribose costs only about one-sixth as much as shikimic acid. In lab studies, the scientists demonstrated the potential use of D-ribose as an alternative source for the synthesis of Tamiflu.

As per the claim by the authors, the concise alternative route  (12 steps) does not utilize protecting groups and features the introduction of 3-pentylidene ketal as the latent 3-pentyl ether, the use of a highly efficient RCM reaction to form the Tamiflu skeleton, and selective functional group manipulations (see Scheme 2, source : Organic Letters)

Ref : http://pubs.acs.org/doi/abs/10.1021/ol9024716